Tauchen, JanJanTauchenBortl, LudvikLudvikBortlHuml, LukasLukasHumlMiksatkova, PetraPetraMiksatkovaDoskocil, IvoIvoDoskocilMarsik, PetrPetrMarsikPanduro Villegas, Pablo PedroPablo PedroPanduro VillegasFlores Bendezu, YmberYmberFlores BendezuVan Damme, PatrickPatrickVan DammeLojka, BohdanBohdanLojkaHavlik, JaroslavJaroslavHavlikLapcik, OldrichOldrichLapcikKokoska, LadislavLadislavKokoska2020-10-032020-11-272020-10-032020-11-272016-06-14Tauchen, J., Bortl, L., Huml, L., Miksatkova, P., Doskocil, I., Marsik, P., Panduro, P., Bendezu, Y., Van Damme, P., Lojka, B., Havlik, J., Lapcik, O., & Kokoska, L. (2016). Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Revista Brasileira de Farmacognosia, 26(6), 728-737. https://doi.org/10.1016/j.bjp.2016.03.0161981-528Xhttp://hdl.handle.net/20.500.12955/114310 PáginasAmong 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 g/ml, respectively). However, combinatory antioxidant/antiproliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 g TE/mg extract; IC50 for Hep-G2 and HT29 at 36.3 and 57.9 g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.Entre los 23 extractos de plantas medicinales y comestibles analizados, Mauritia flexuosa L.f., Arecaceae, mostró una capacidad antioxidante significativa (DPPH y ORAC = 1062,9 y 645,9 ± 51,4 g TE/mg extracto, respectivamente), mientras que Annona montana Macfad., Annonaceae, demostró el efecto antiproliferativo más prometedor (IC50 para Hep-G2 y HT-29 = 2,7 y 9,0 g/ml, respectivamente). Sin embargo, sólo se detectó un efecto antioxidante/antiproliferativo combinatorio en Oenocarpus bataua Mart., Arecaceae (DPPH = 903,8 y ORAC = 1024 g TE/mg extracto; IC50 para Hep-G2 y HT-29 a 102,6 y 38,8 g/ml, respectivamente) e Inga edulis Mart, Fabaceae (DPPH = 337,0 y ORAC = 795,7 g TE/mg extracto; IC50 para Hep-G2 y HT29 a 36,3 y 57,9 g/ml, respectivamente). El contenido fenólico se correlacionó positivamente con el potencial antioxidante, pero no con el efecto antiproliferativo. Ninguno de estos extractos resultó tóxico para las células pulmonares fetales normales, lo que sugiere su posible uso en el desarrollo de nuevos agentes vegetales con acción preventiva y/o terapéutica contra las enfermedades relacionadas con el estrés oxidativo.Abstract. Introduction. Materials and methods. Results. Discussion. Conclusion. References.enginfo:eu-repo/semantics/openAccessAntioxidantAnticarcinogenicPhenolic compoundsPlant extractsPhenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazoninfo:eu-repo/semantics/article10.1016/j.bjp.2016.03.016https://purl.org/pe-repo/ocde/ford#4.04.01